Biomarkers and genetic variants reflect disease course in multiple sclerosis
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چکیده
منابع مشابه
Association Between MTHFR Genetic Variants and Multiple Sclerosis in a Southern Iranian Population
Multiple sclerosis (MS) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. Genetic predisposition has long been suspected in the etiology of this disease. The association between MTHFR polymorphisms and MS has been ivestigated in different ethnic groups. We investigated the association between MTHFR C677T and A1298C missense variants and MS in 180 patients ...
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background multiple sclerosis (ms) is an autoimmune disease that affects the central nervous system (cns). ms is one of the most common cause of neurological impairment at a young age with a complex etiology. the forkhead/winged helix (foxp3) gene encodes a transcription factor that plays an important role in the working and progress of regulatory t cells. loss of the foxp3 function impairs the...
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BACKGROUND The genetic drivers of multiple sclerosis (MS) clinical course are essentially unknown with limited data arising from severity and clinical phenotype analyses in genome-wide association studies. METHODS Prospective cohort study of 127 first demyelinating events with genotype data, where 116 MS risk-associated single nucleotide polymorphisms (SNPs) were assessed as predictors of con...
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Roland Martina, Bibiana Bielekovab, Reinhard Hohlfeldc and Ursula Utzd,∗ Catalan Institute for Research and Advanced Studies and Unidad de Neuroimmunologia Clinica, Hospital Universitari Vall d’Hebron, Barcelona, Spain Department of Neurology, Waddel Center for MS, University of Cincinnati & The Neuroscience Institute, Cincinnati, OH, USA Department of Neuroimmunology, Max-Planck-Institute of N...
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From a neuropathological perspective, elderly patients who die with a clinical diagnosis of sporadic Alzheimer's disease (AD) are a heterogeneous group with several different pathologies contributing to the AD phenotype. This poses a challenge when searching for low effect size susceptibility genes for AD. Further, control groups may be contaminated by significant numbers of preclinical AD pati...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2016
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2016.142